The California Department of Public Health (CDPH) is releasing this Health Advisory to inform healthcare providers about the recent increase in tuberculosis (TB) cases in California. CDPH encourages providers to consider tuberculosis in their differential diagnoses, to test persons with risk factors for tuberculosis, and to offer treatment to those with latent tuberculosis infection (LTBI) to prevent progression to active TB disease. Healthcare providers in California are required to report TB cases to their local public health department.