CDPH Update: Powdered Benzathine Benzylpenicillin (Extencilline®) for the Treatment of Syphilis

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Published on February 02, 2024. Last modified on November 08, 2024

Powdered Benzathine Benzylpenicillin (Extencilline®) for the Treatment of Syphilis

  • CDPH sent this communication to all health care providers regarding the use of powdered benzathine benzylpenicillin (Extencilline®) for the treatment of syphilis.
  • To address the ongoing shortage of benzathine penicillin G injectable suspension (Bicillin® L-A), the U.S. Food and Drug Administration (FDA) coordinated the temporary importation of Extencilline® (PDF) and associated diluent for reconstitution of  injectable 1.2 million- and 2.4-million-unit doses.
  • Benzathine benzylpenicillin is an alternative name for benzathine penicillin G, therefore Extencilline® and Bicillin® L-A are equivalent and can be used interchangeably for the treatment of syphilis. 

View the Complete Advisory Here: Powdered Benzathine Benzylpenicillin (Extencilline®) for the Treatment of Syphilis 

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